Table 1.

Significant genome-wide association hit SNPs (discovery p < 5·10⁻⁸ and replication p < 0.05)

Feature	chr	Pos	rsid	Sulcus	Discovery (12,162)		Replication (3435)		Nearest gene
					β	p val	β	p val
Opening	1	215134722	rs755576	FCMpost left *	− 0.101	1.7·10−9	− 0.075	0.02	KCNK2
	1	215135752	rs6667184	FCMpost left *	− 0.052	2.6·10−9	− 0.046	6.2·10−3	KCNK2
	1	215140283	rs504473	FCMpost left	0.053	2.2·10−8	0.043	0.02	KCNK2
	1	215150260	rs864736	FCMpost left *	0.063	2.3·10−14	0.064	3.2·10−5	KCNK2
				FCMpost right *	0.061	3.8·10−14	0.061	4.7·10−5
	1	215154276	rs59084003	FCMpost left *	− 0.121	3.0·10−14	− 0.083	5.1·10−3	KCNK2
				FCMpost right *	− 0.116	7.9·10−14	− 0.073	0.01
				FIP left *	− 0.071	9.7·10−10	− 0.044	0.04
				FIP right *	− 0.072	3.4·10−11	− 0.062	1.8·10−3
				SC right	− 0.074	2.7·10−9	− 0.058	0.01
				SsP left	− 0.061	5.6·10−9	− 0.042	0.02
	1	215186121	rs2841614	FCMpost left	− 0.093	4.1·10−9	− 0.084	5.1·10−3	KCNK2
	1	215191552	rs1452608	FCMpost left *	− 0.054	5.2·10−11	− 0.044	4.7·10−3	KCNK2
	1	215135752	rs6667184	FCMpost right *	− 0.058	1.5·10−11	− 0.046	4.0·10−3	KCNK2
	9	113699603	rs10980645	SC left	0.038	4.5·10−8	0.033	0.01	LPAR1
	12	106476805	rs12146713	STs right *	0.05	9.3·10−10	0.031	0.03	NUAK1
	16	87226206	rs9933149	SFinf left	− 0.031	5.0·10− 8	− 0.05	1.7·10−6	C16orf95
				STs left *	− 0.033	2.6·10−11	− 0.019	0.03
				STs right *	− 0.031	2.2·10−10	− 0.024	8.2·10−3
	16	87237863	rs4843549	SFinf left	− 0.033	5.5·10−9	− 0.047	5.9·10−6	C16orf95
GM thickness	1	215150260	rs864736	FCMpost left *	− 0.023	8.3·10−10	− 0.02	6.2·10−3	KCNK2
				FCMpost right *	− 0.024	9.6·10−10	− 0.019	0.01
	1	215154276	rs59084003	FIP right *	0.037	7.3·10−10	0.037	5.6·10−4	KCNK2
	8	11836318	rs11774568	FCLp left	0.018	4.2·10−8	0.017	4.9·10−3	DEFB135

Bold rsid correspond to variants that are further investigated in Fig. 3, the remainders are in Figures S7–S8. Position are given in the GRCh37 build. Significant associations after accounting for multiple testing burden due to the phenotypes (p < 2.6·10⁻⁹) are emphasized with *