Figure 1.

Participant flow diagram.^aExclusion criteria were as follows: previous diagnosis of osteoarthritis; age younger than 35 years; diagnosis of rheumatoid arthritis, fibromyalgia, and recurrent or active pseudogout; presence of cancer or other decompensating conditions; kidney or liver failure; asthma requiring the use of steroids or oral corticosteroids within past 4 weeks; use of intra-articular corticosteroids within the past 12 weeks; use of hyaluronate within the past 6 months; knee arthroscopy within the past year; knee replacement on study knee; significant knee injury within past 6 months; presence of a rash or open wound over the knee; current regular use of massage therapy.