Table 1.
Recent epidemiological studies reporting on fertility in childhood and young adult cancer survivors
| Study | Design | Diagnoses of cases | N. exposed women (age) | Main results |
|---|---|---|---|---|
| Madanat et al., 2008 [1] | Linking of Finnish registers of cancer and the one of central population. Comparisons were made with siblings identified with the second register. | All cancers | 1334 (0–14 years) + 1254 (15–19 years) | RR = 0.62 (95% CI 0.56–0.68) for age 0–14 and RR = 0.64 (95% CI 0.58–0.70) for age 15–19. |
| Reulen et al., 2009 [2] | British cohort study with active follow-up (quesyionnaires). Comparison with the expected pregnancy rates in the general population | All cancers | 10,483 (0–14 years) | O/E 0.64 (96% CI 0.62–0.66) |
| Stansheim et al., 2011 [3] | Linking of Norway registers of cancer and birth. Comparison with matched unexposed women of the National register. | All cancers | not reported (subset of women aged 16–25 years) | HR = 0.67 (95% CI 0.63–0.73) |
| Pivetta et al., 2011 [4] | Multicenter hospital-based Italian cohort study. Comparison with the expected pregnancy rates in the general population | All cancers | 1888 (0–14 years) | O/E 0.57 (96% CI 0.53–0.62) |
| Bramswig et al., 2015 [5] | Prospective German cohort study (patients included in 5 trials). Comparison with the general population. | Hodgkin’s lymphoma | 554 (0–17 years) | No significant difference with the exception of those seeking at 40–44 years (61% vs 78%, p = 0.001). |
| Chow et al., 2016 [6] | Cohort study from 27 Institutions in the USA and Canada (CCSS: Childhood Cancer Survivor Study). Controls were siblings. | All cancers (exclusion of girls requiring brain or pelvis radiotherapy) | 2455 (0–20 years) | HR = 0.82 (95% CI 0.75–0.90) |
| Armuand et al., 2017 [7] | Use of the Sweden national patient register. Comparison with matched unexposed women of the general population (same register). | All cancers | 552 (0–20 years) | HR = 0.82 (95% CI 0.72–0.95) |
| Anderson et al., 2018 [8] | Linking of Scottish registers of cancer, pregnancies and death. Comparison with the expected pregnancy rates in the general population | All cancers | 1638 (0–14 years) + 2674 (15–24 years) | SIR = 0.72 (95% CI 0.66–0.78) for age 0–14 and SIR = 0.69 (95% CI 0.66–0.72) for age 15–24. |
Only studies published during the last decade are included
If identified studies overlapped for study population, only the most recent one was included
SIR standardized incidence ratio, HR hazard ratio, O/E observed/expected ratio