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. 2019 Mar 15;9:4646. doi: 10.1038/s41598-019-40991-y

Figure 3.

Figure 3

In vivo infection assay in Galleria mellonella model. (A) Survival of G. mellonella after H. pylori 11F/11 infection with PBS, MIC of LVX, 1000 mg/kg of P. vera L. ORS and the best synergistic combination of P. vera L. ORS and LVX (90 mg/l ORS + 0.12 mg/l LVX, FIC I = 0.18). Kaplan-Meier survival curves of G. mellonella larvae after infection with 1.8 × 106 CFUs. Differences in survival were calculated using the Long-rank test for multiple comparison. (B) Recovery of H. pylori 11F/11 CFU/larva in G. mellonella larvae after injection of 1.8 × 106 CFUs after different time points and at different conditions (PBS, LVX at MIC value, P. vera L. ORS at 1000 mg/kg, the best synergistic combination of P. vera L. ORS and LVX).*Statistically significant in respect to sham injection, at each time control (p ≤ 0.05).