Table 1.
H. pylori strains | P. vera L. ORS (mg/l) | LVX (mg/l) | Best combination ORS + LVX (mg/l)# | FIC I* | ||||||
---|---|---|---|---|---|---|---|---|---|---|
MIC | MBC | MIC | MBC | |||||||
pH | pH | pH | pH | |||||||
7.0 | 5.5 | 7.0 | 5.5 | 7.0 | 5.5 | 7.0 | 5.5 | |||
11F/11 | 1560 | 1560 | 1560 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 90 + 0.12 | 0.18 |
2A/12 | 1560 | 3120 | 3120 | 6250 | 0.50 | 1.00 | 0.50 | 1.00 | 190 + 0.12 | 0.36 |
3F/12 | 1560 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.12 | 0.37 |
4A/12 | 1560 | 3120 | 1560 | 3120 | 0.50 | 0.50 | 0.50 | 0.50 | 390 + 0.12 | 0.49 |
7A/12 | 1560 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.25 | 0.50 |
9A/12 | 780 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 190 + 0.25 | 0.49 |
12F/12 | 3120 | 3120 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 780 + 0.25 | 0.50 |
13A/12 | 1560 | 3120 | 1560 | 3120 | 0.50 | 0.50 | 0.50 | 0.50 | 390 + 0.12 | 0.49 |
1F/13 | 1560 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.25 | 0.50 |
3F/13 | 780 | 780 | 1560 | 1560 | 0.50 | 0.50 | 0.50 | 0.50 | 190 + 0.12 | 0.48 |
4A/13 | 3120 | 3120 | 6250 | 6250 | 0.50 | 0.50 | 1.00 | 1.00 | 780 + 0.12 | 0.49 |
5A/13 | 1560 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.25 | 0.50 |
10A/13 | 1560 | 3120 | 1560 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.25 | 0.50 |
13A/13 | 1560 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.25 | 0.50 |
20A/13 | 1560 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.25 | 0.50 |
23A/13 | 1560 | 3120 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 190 + 0.12 | 0.24 |
24F/13 | 780 | 1560 | 1560 | 1560 | 1.00 | 1.00 | 1.00 | 1.00 | 190 + 0.12 | 0.36 |
25F/13 | 1560 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.25 | 0.50 |
26A/13 | 3120 | 3120 | 6250 | 6250 | 2.00 | 2.00 | 2.00 | 2.00 | 780 + 0.25 | 0.37 |
5F/14 | 3120 | 3120 | 6250 | 6250 | 1.00 | 1.00 | 1.00 | 1.00 | 780 + 0.12 | 0.37 |
10A/14 | 1560 | 1560 | 6250 | 6250 | 0.50 | 0.50 | 0.50 | 0.50 | 190 + 0.12 | 0.36 |
29A/14 | 1560 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.12 | 0.37 |
3F/15 | 780 | 780 | 780 | 1560 | 1.00 | 1.00 | 1.00 | 1.00 | 190 + 0.12 | 0.36 |
4A/15 | 1560 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.25 | 0.50 |
8F/15 | 1560 | 1560 | 1560 | 1560 | 0.50 | 0.50 | 0.50 | 0.50 | 390 + 0.12 | 0.49 |
30A/15 | 1560 | 1560 | 1560 | 3120 | 0.50 | 0.50 | 0.50 | 0.50 | 390 + 0.12 | 0.49 |
1A/16 | 1560 | 1560 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.25 | 0.50 |
5A/16 | 1560 | 1560 | 1560 | 1560 | 1.00 | 1.00 | 1.00 | 1.00 | 190 + 0.12 | 0.24 |
7F/16 | 3120 | 3120 | 3120 | 3120 | 0.50 | 0.50 | 0.50 | 0.50 | 780 + 0.12 | 0.49 |
14A/16 | 3120 | 3120 | 3120 | 3120 | 1.00 | 1.00 | 1.00 | 1.00 | 390 + 0.25 | 0.37 |
9F/13 | 1560 | 1560 | 3120 | 3120 | 0.12 | 0.12 | 0.12 | 0.12 | 390 + 0.03 | 0.50 |
ATCC 43629 | 3120 | 3120 | 6250 | 6250 | 0.12 | 0.12 | 0.12 | 0.12 | 1560 + 0.03 | 0.75 |
*See Materials and Methods. #Combination of sub-MIC of P. vera L. ORS and LVX yielding the lowest FIC I, that is the best combination. Synergisms (FIC I ≤ 0.5) were detected in 31 out of 32 strains and an additive effect (FIC I > 0.5–4.0) was displayed in the reference H. pylori strain. Antagonism was not recorded (FIC I ≥ 4.0).