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. 2019 Mar 15;2:106. doi: 10.1038/s42003-019-0351-4

Fig. 7.

Fig. 7

Schematic of regulation cascade from MafA through CaVγ4 to insulin secretion in beta cell. Compared with healthy beta cell, dedifferentiated beta cell caused by T2D or glucotoxicity results in reduced MafA expression, which leads to the downregulation of its direct downstream target CaVγ4. Decreased CaVγ4 expression then diminishes L-type CaV channels expression with consequent preventing of Ca2+ influx and in turn blunting of GSIS