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. 2019 Mar 15;9:4638. doi: 10.1038/s41598-019-40915-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome analysis of undifferentiated hiPSCs using miRNA array and GeneChip array. (a) Plot showing expression of relative fold change expression between high and low differentiation groups. The x-axis indicates miRNA ranks for relative fold change and the y-axis shows the expression ratio (high/low) based on the differential profiles of 535 miRNAs in hiPSCs. (b) The differential expression of miRNAs in the high differentiation and low differentiation groups at a p < 0.05 and FC > 2. Data are expressed as mean ± SEM (n = 3). **p < 0.01; *p < 0.05, t-test. (c) Scatter plot showing counts per million (CPM) of high differentiation (y-axis) vs. CPM of low differentiation (x-axis) from the mRNA array analysis. Red and blue coloured points and gene names indicate mRNAs that were significantly changed (FC > 2 and p < 0.01, t-test). (d) Graph showing the fold changes of the top and bottom differentially expressed genes from a GeneChip analysis comparing the high differentiation group with the low differentiation group. Selected genes have been colour-coded and labelled. Red, top 10 expression in the high differentiation group (p < 0.01, t-test); blue, top 10 expression in the low differentiation group (p < 0.01). (e) Pathway analysis of the collective expression levels of interacting genes involved in specific pathways.