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. 2019 Mar 15;10:1225. doi: 10.1038/s41467-019-08933-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Acute epileptiform activity induced by pilocarpine injections in the mouse visual cortex. a Left: diagram showing the cannula guide location over the site of pilocarpine injection, ElectroCorticoGram (ECoG) recording and photostimulation in the visual cortex V1 area. Right: immunofluorescence of PV+ interneurons expressing ChR2-EYFP (green), cell nuclei staining DAPI (blue) and DiI co-injected with pilocarpine (magenta). Restricted DiI spread suggests that pilocarpine has a local action. b ECoG traces showing three different types of epileptiform activity induced by pilocarpine (States 1, 2, 3). c 3D plot of the linear discriminant analysis demonstrates network state separation on the training (open circles) and test (filled triangles) ECoG samples. Each linear discriminant (LD1, LD2, LD3) corresponds to a particular combination of weights of the 20 features extracted from ECoG traces. d Performance of the random forest network state classifier expressed as a Receiver Operating Characteristic (ROC) curve. TP true positives, FP false positives. The dashed line shows random allocation of events. Source data are provided as a Source Data file