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. 2018 Oct 1;29(4):1893–1902. doi: 10.1007/s00330-018-5738-y

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Microvascular characteristics of different molecular subtypes of lower-grade gliomas. a Microvascular characteristics of different molecular subtypes in grade-II gliomas. All the subtypes showed low perfusion on vessel size imaging maps, and the perfusion of the IDH-mutant with 1p/19q-intact (IDH^MUT/1p/19q⁺) type (male, 48 years) was higher than that of the IDH-mutant with 1p/19q-codeleted (IDH^MUT/1p/19q⁻) type (female, 46 years) and the IDH-wild (IDH^WT) type (female, 40 years). CD34 staining results demonstrated that the angiogenesis of the IDH^MUT/1p/19q⁻ and IDH^WT type are more exuberant than that of the IDH^MUT/1p/19q⁺ type, evidenced by higher microvascular density and smaller diameter for the former. b Microvascular characteristics of different molecular subtypes in grade-III gliomas. All the subtypes showed high perfusion on vessel size imaging maps and exuberant angiogenesis on CD34 stained sections