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. 2019 Mar 15;9:4634. doi: 10.1038/s41598-019-41078-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Co-occurence of CNAs in B-cell development genes in the different BCP-ALL subtypes. Heatmap of CNA profile of 515 newly diagnosed pediatric BCP-ALL patients, representing the major BCP-ALL subtypes. CNAs are shown per subtype. Colors indicate presence of a CNA and absence of CNAs is shown in white. The heatmap is sorted on IKZF1 deletions followed by CNAs in PAX5. Each column represents an individual patient. The co-occurrence between the different CNAs in all BCP-ALL cases was calculated using the Fisher Exact test. Odds ratios and p-values of significant associations are shown.