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. 2019 Mar 15;9:4634. doi: 10.1038/s41598-019-41078-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Prognostic value of CNAs in DCOG-ALL10 treated cases. (A) The association between CNAs in all risk groups and cumulative incidence of relapse (CIR) and event-free-survival (EFS) was examined. BCP-ALL patients (n = 210) were treated according to DCOG-ALL10 protocol. CIR was estimated using a competing risk model. Relapse and non-response were considered as event, and death as competing event. To test equality of the CIRs, the Gray’s test was applied. Non-response, relapse, and death were considered as events for EFS. EFS rates were determined using Cox regression, and compared using the Wald test. For reliable test results, groups should contain at least 5 cases. (B) CIR and EFS curves of cases without or with an IKZF1 deletion. Curves contain either all risk groups, or the medium risk arm only.