Table 1.

Serotonin transporter gene polymorphisms in patients with multiple sclerosis (MS) in comparison to healthy control

Serotonin transporter gene			Depression scores (BDI-II) in patients with MS [n (%)]				All patients with MS (n = 100)	Healthy controls (n = 100)	P
			Mild depression (n = 26)	Moderate depression (n = 15)	No depression (n = 52)	Undefined (n = 7)
Alleles [n (%)]	5-HTTLPR	LA	25 (48.1)	12 (40.0)	53 (51.0)	7 (50.0)	97 (48.5)	102 (51.0)	0.34
		LG	0 (0)	2 (6.7)	0 (0)	0 (0)	2 (1.0)	0 (0)
		S	27 (51.9)	16 (53.3)	51 (49.0)	7 (50.0)	101 (50.5)	98 (49.0)
	STin2VNTR	10	15 (28.8)	10 (33.3)	35 (33.7)	4 (28.6)	64 (32.0)	72 (36.0)	0.39
		12	37 (71.2)	20 (66.7)	69 (66.3)	10 (71.4)	136 (68.0)	128 (64.0)
Genotypes [n (%)]	5-HTTLPR	LA/LA	6	3	15	2	26	26	0.67
		LG/LG	0 (0)	1 (3.3)	0 (0)	0 (0)	1	0
		LA/S	13 (25.0)	6 (20.0)	23 (22.1)	3 (21.4)	45	50
		S/S	7 (13.5)	5 (16.7)	14 (13.5)	2 (14.3)	28	24
	STin2VNTR	10/10	0	2	5	1	8	13	0.51
		10/12	15	6	25	2	48	46
		12/12	11	7	22	4	44	41
Genotype combinations	LA/LA, 10/10		0	2	4	1	7	12	0.11
	LA/LA, 10/12		5	1	10	1	17	10
	LA/LA, 12/12		1	0	1	0	2	4
	LG/LG, 12/12		0	1	0	0	1	0
	LA/S, 10/10		0	0	0	0	0	1
	LA/S, 10/12		9	5	12	1	27	25
	LG/LG, 12/12		4	1	11	2	18	24
	S/S, 10/10		0	0	1	0	1	0
	S/S, 10/12		1	0	3	0	4	11
	S/S, 12/12		6	5	10	2	23	13
Haplotypes	LA-10		0.26	0.33	0.28	0.29	0.28	0.28	NS
	LA-12		0.22	0.07	0.23	0.14	0.20	0.23
	LG-12		0.00	0.07	0.00	0.00	0.01	0.00
	S-10		0.03	0.00	0.06	0.00	0.04	0.08
	S-12		0.49	0.53	0.43	0.57	0.47	0.41

MS: Multiple sclerosis; BDI-II: Beck Depression Inventory-II; NS: Not significant