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. 2019 Feb 18;7(1):31–45.

Figure 5.

Figure 5

Machinery of IFIT5-mediated miRNA degradation is enhanced in the metastatic progression of RCC. A. Expression level of IFIT5, SNAI2/Slug, ZEB1, IFNGR1 and IFNGR2 in paired adjacent benign and tumor specimens derived from 75 RCC patients. B. Expression of IFIT5 in the patient-derived xenografts from normal benign (N=191), primary (N=294) and metastatic tumors (N=86) of RCC patients. Expression level of IFNGR1 and IFNGR2 genes in tumor specimens derived from RCC patients with non-metastasis (M0, N=550) and metastasis (M1, N=90) status. C. Kaplan-Meier overall survival curves estimate patients with RCC including types of clear cell RCC, papillary RCC and Chromophobe RCC, stratified in low and high expression of IFIT5, IFNGR1 or IFNGR2 genes. D. Clinical correlation between IFIT5 and SNAI2(Slug), ZEB1, IFNGR1 or IFNGR2 in TCGA dataset derived from 888 RCC patient tumor specimens.