Table 1.
vegfr2 (KDR) is highly associated with eltd1. GAMMA-predicted association analysis identifies the top 8 genes associated with eltd1 based on GAMMA scores
| Gene | Function | Ref. |
|---|---|---|
| FLT4 (Vascular Endothelial Growth Factor Receptor 3) | Involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. | [49-53] |
| KDR (Vascular Endothelial Growth Factor Receptor 2) | Main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. | [54-58] |
| ANGPT2 (Angiopoietin 2) | Regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. | [47,59-61] |
| MMP1 (Matrix Metallopeptidase 1) | Involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. | [62-66] |
| CDH5 (Cadherin 5) | Plays an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. | [67-71] |
| PTK2 (Protein Tyrosine Kinase 2) | Plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis | [72-76] |
| FLT1 (Vascular Endothelial Growth Factor Receptor 1) | Acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion | [77-81] |
| PDGFRB (Platelet Derived Growth Factor Receptor Beta) | Plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. | [82-86] |