Table 2.
Types of 68Ge/68Ga generators
| Years | Generator type | Remarks |
|---|---|---|
| 1960-1970 | liquid-liquid extraction | Tedious time consuming separation; not amenable for hospital radiopharmacy. |
| 1970-2000 | Column chromatography system based on Al2O3 and EDTA as eluent | This system served as a convenient and economical source of 68Ga-EDTA; clinical use was limited to measure increased blood flow of brain tumors, in particular. |
| After 2000 | Column chromatography system based on TiO2, ZrO2, CeO2, SnO2 or an organic resin | 68Ga is availed in an ionic form, with elution yields 70% to 80%; 68Ge breakthrough still in the range, 0.01-0.001%. |