A-C, In vitro myelin sheet formation by FB and SC OLCs. Representative immunocytochemistry
for MBP of FB (A) and SC OLCs (B) at day 4 in differentiation medium. Arrows indicate typical MBP+
myelin sheets observed in FB MOs. Scale bar: 50 μm. C shows the quantification of area covered by MBP
immunoreactivity in FB and SC OLC cultures. D-E, Expression of myelin proteins in differentiated FB and SC OLs in
vitro. Representative Western blots for MBP, PLP, MOG and CNP (D), and the quantification (E). FB and SC
cells were plated at x1 and x4 density, respectively. ** indicates p<0.01 (n=3 independently prepared cultures/group,
Student’s t-test).