Table 2.
Multivariable logistic regression for analyzing the bone metastases associated factors in different histological types of lung cancer
| Variable | Patients, N. | Entire cohort | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Bone metastasis N (%) | Bone metastasis N (%) | Adenocarcinoma | Squamous | SCLC | LC | NSCLC/NOS | ||||||
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |||
| Sex | ||||||||||||
| Female | 46,496 (47.8) | 10,752 (41.9) | ref | 1.0 | ref | 1.0 | ref | 1.0 | ref | 1.0 | ref | 1.0 |
| Male | 50,750 (52.2) | 14,893 (58.1) | 1.24 (1.15–1.34) | < 0.001 | 1.32 (1.15–1.51) | < 0.001 | 1.33 (1.23–1.45) | < 0.001 | 1.32 (1.01–1.72) | 0.042 | 1.37 (1.21–1.55) | < 0.001 |
| Metastatic sites | ||||||||||||
| 0 site | 71,363 (73.3) | 10,192 (40.0) | ref | 1.0 | ref | 1.0 | ref | 1.0 | ref | 1.0 | ref | 1.0 |
| 1 site | 21,085 (21.7) | 10,071 (39.6) | 3.39 (3.11–3.70) | < 0.001 | 3.98 (3.47–4.57) | < 0.001 | 2.95 (2.69–3.23) | < 0.001 | 2.87 (2.16–3.81) | < 0.001 | 3.34 (1.91–3.82) | < 0.00` |
| 2 sites | 4339 (4.5) | 4331 (17.0) | 6.47 (5.68–7.36) | < 0.001 | 8.22 (6.40–10.54) | < 0.001 | 5.55 (4.89–6.30) | < 0.001 | 6.23 (4.22–9.21) | < 0.001 | 5.29 (4.34–6.45) | < 0.001 |
| 3 sites | 439 (0.5) | 868 (3.4) | 12.08 (8.65–16.87) | < 0.001 | 13.64 (7.73–24.08) | < 0.001 | 7.57 (5.57–10.29) | < 0.001 | 5.97 (2.02–17.62) | 0.001 | 10.38 (6.73–16.01) | < 0.001 |
| Tumor size | ||||||||||||
| < 2 cm | 14,785 (17.7) | 1996 (10.0) | ref | 1.0 | ref | 1.0 | ref | 1.0 | ref | 1.0 | ref | 1.0 |
| 2–5 cm | 41,463 (49.7) | 10,122 (51.0) | 1.83 (1.60–2.11) | < 0.001 | 1.66 (1.23–2.25) | 0.001 | 1.42 (1.22–1.65) | < 0.001 | 1.28 (0.82–2.00) | 0.28 | NS | NS |
| 5–10 cm | 23,894 (28.7) | 6859 (34.6) | 1.99 (1.72–2.31) | < 0.001 | 1.95 (1.44–2.64) | < 0.001 | 1.38 (1.19–1.61) | < 0.001 | 1.52 (0.97–2.40) | 0.07 | NS | NS |
| > 10 cm | 3210 (3.9) | 875 (4.4) | 1.55 (1.21–2.00) | < 0.001 | 1.86 (1.26–2.73) | < 0.001 | 1.35 (1.10–1.66) | 0.004 | 1.61 (0.87–2.97) | 0.13 | NS | NS |
| Histological type | ||||||||||||
| Well differentiated | 6441 (11.8) | 372 (4.1) | ref | 1.0 | ref | 1.0 | ref | 1.0 | ref | 1.0 | ref | 1.0 |
| Moderate differentiated | 18,285 (33.4) | 2149 (23.6) | 1.49 (1.27–1.75) | < 0.001 | 0.81 (0.53–1.22) | 0.31 | NS | NS | NS | NS | 2.31 (1.61–3.32) | < 0.001 |
| Poor differentiated | 26,632 (48.7) | 5681 (62.4) | 1.52 (1.30–1.78) | < 0.001 | 1.26 (0.84–1.88) | 0.27 | NS | NS | NS | NS | 4.65 (3.36–6.42) | < 0.001 |
| Undifferentiated | 3315 (6.1) | 909 (10.0) | 1.80 (1.24–2.62) | < 0.001 | 2.05 (1.07–3.92) | 0.03 | NS | NS | NS | NS | 4.56 (3.10–6.70) | < 0.001 |
| Lymphatic metastasis | ||||||||||||
| N0 | 38,449 (40.4) | 4325 (17.8) | ref | 1.0 | ref | 1.0 | ref | 1.0 | ref | 1.0 | ref | 1.0 |
| N1 | 8708 (9.2) | 1985 (8.2) | 1.77 (1.53–2.05) | < 0.001 | 1.82 (1.45–2.29) | < 0.001 | 1.30 (1.06–1.61) | 0.013 | 2.29 (1.41–3.70) | 0.001 | 1.99 (1.59–2.50) | < 0.001 |
| N2 | 35,358 (37.2) | 12,297 (50.6) | 3.39 (3.07–3.75) | < 0.001 | 3.07 (2.61–3.61) | < 0.001 | 1.85 (1.60–2.13) | < 0.001 | 2.89 (2.05–4.08) | < 0.001 | 2.39 (2.04–2.80) | < 0.001 |
| N3 | 12,635 (13.3) | 5682 (23.4) | 3.92 (3.46–4.45) | < 0.001 | 3.23 (2.62–3.99) | < 0.001 | 2.56 (2.20–2.99) | < 0.001 | 2.94 (1.94–4.45) | < 0.001 | 2.96 (2.43–3.61) | < 0.001 |
SCLC small cell lung cancer, LC large cell, NOS not otherwise specified, NSCLC non-small cell lung cancer, NS not significant