Table 1.
Baseline demographic characteristics of participants of C-STRIDE Study according to NLR
| Variable | Total (n = 938) | NLR ≥ 2.09 (n = 520) | NLR < 2.09 (n = 418) | p value |
|---|---|---|---|---|
| Age (year)* | 52.8 (14.14) | 54.0 (14.48) | 51.3 (13.58) | 0.047** |
| Sex (men)$ | 544 (58.00%) | 304 (58.46%) | 240 (57.42%) | 0.747 |
| Ever smoking$ | 311 (34.2%) | 180 (35.7%) | 131 (32.3%) | 0.276 |
| Drinking ≥ 1 times per day$ | 189 (21.00%) | 101 (20.2%) | 88 (22.0%) | 0.510 |
| BMI category (kg/m2)# | 24.61 (22.04–27.34) | 24.61 (22.01–27.42) | 24.59 (21.99–27.31) | 0.944 |
| HGB (g/L)* | 129.2 (22.78) | 125.7 (23.00) | 133.70 (21.71) | 0.183 |
| Systolic blood pressure (mmHg)* | 127.51 (16.71) | 129.91 (17.88) | 124.92 (14.96) | 0.537 |
| Diastolic blood pressure (mmHg)* | 80.13 (10.48) | 81.11 (11.01) | 79.08 (9.78) | 0.918 |
| Antihypertensive medications token in 2 weeks$ | 507 (69.5%) | 288 (74.0%) | 219 (64.4%) | 0.005** |
| Hypertension$ | 538 (57.4%) | 303 (58.3%) | 235 (56.2%) | < 0.001** |
| Uric acid (μmol/L)* | 373.59 (132.08) | 376.59 (136.42) | 369.87 (126.55) | 0.208 |
| Serum triglycerides (mmol/L)# | 1.66 (1.18–2.39) | 1.61 (1.13–2.26) | 1.79 (1.21–2.59) | 0.021** |
| Hyperuricemia$ | 407 (44.3%) | 235 (46.2%) | 172 (42.0%) | 0.201 |
| Total serum cholesterol (mmol/L)# | 4.70 (4.01–5.57) | 4.59 (3.94–5.39) | 4.82 (4.12–5.89) | 0.003** |
| LDL cholesterol (mmol/L)# | 2.73 (2.22–3.40) | 2.72 (2.20–3.36) | 2.74 (2.23–3.48) | 0.369 |
| HDL cholesterol (mmol/L)# | 1.12 (0.91–1.34) | 1.12 (0.93–1.34) | 1.12 (0.89–1.34) | 0.729 |
| Hyperlipidaemia$ | 194 (26.6%) | 98 (23.7%) | 96 (30.5%) | 0.039** |
| Cardiovascular disease$ | 124 (13.40%) | 81 (15.80%) | 43 (10.40%) | 0.017** |
| ACR (mg/g creatinine)# | 343.05 (75.60–780.51) | 420.50 (112.11–312.90) | 290.01 (48.20–666.86) | 0.000** |
| ACR group$ | 814 | 447 | 367 | 0.006** |
| 1 < 30 mg/g | 127 (15.6%) | 56 (12.5%) | 71 (19.3%) | |
| 2 = 30–299 mg/g | 248 (30.5%) | 130 (29.1%) | 118 (32.2%) | |
| 3 ≥ 300 mg/g | 439 (53.9%) | 261 (58.4%) | 178 (48.5%) | |
| sCa (mmol/L)* | 2.22 (0.18) | 2.23 (0.18) | 2.22 (0.18) | 0.735 |
| sP (mmol/L)# | 1.17 (1.05–1.31) | 1.17 (1.04–1.31) | 1.18 (1.05–1.32) | 0.925 |
| CKD-MBD$ | 467 (54.6%) | 274 (58.1%) | 193 (50.3%) | 0.023** |
| HCO3− (mmol/L)* | 25.70 (3.78) | 25.54 (3.99) | 25.91 (3.49) | 0.060 |
| Diabetes$ | 200 (23.8%) | 135 (29.4%) | 65 (17.1%) | 0.000** |
| eGFR (mL/min/1.7 m2)* | 57.22 (32.67) | 48.73 (29.63) | 67.78 (33.24) | 0.000** |
| eGFR group$ | 938 | |||
| ≥ 60 mL/min/1.73 m2 | 360 (38.4%) | 139 (26.7%) | 221 (52.9%) | 0.000** |
| 30–60 mL/min/1.73 m2 | 345 (36.8%) | 212 (40.8%) | 133 (31.8%) | |
| 15–30 mL/min/1.73 m2 | 233 (24.8%) | 169 (32.5%) | 64 (15.3%) | |
| High hs-CRP | 146 (15.6%) | 88 (16.9%) | 58 (13.9%) | 0.414 |
The number of missing values for each variable: NLR 0, age 0, eGFR 0, sex 0, education 31, ever smoking 51, drinking ≥ 1 times per day 60, BMI category 211, anemia 0, systolic blood pressure 186, diatolic blood pressure 186, antihypertensive medications token in 2 weeks 334, uric acid 30, total serum cholesterol 338, serum triglycerides 347, LDL cholesterol 428, HDL cholesterol 425, CKD-MBD 0, cardiovascular disease 28, ACR 149, metabolic acidosis 589, pathogenesis chronic 0, high Hs-CRP 668
The denominator of percentage is number of the variable
* The variable is numerical and statistics is mean (standard deviation), p-value calculated based on T test
#The variable is numerical and statistics is Median (Interquartile range), p-value calculated based on Wilcoxon test
$The variable is character and statistics is frequency (percentage), p-value calculated based on Chi-square test
** Statistically significant at 0.05