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. 2019 Feb;10(1-2):1–10. doi: 10.18632/genesandcancer.184

Figure 5. Collagen expression was significantly reduced after treatment with EC359.

Figure 5

The qRT-PCR analyses of expression of various collagen performed on 3D co-culture organoids. The reduction in collagen expression in 3D model was significantly different across different treatments. Collagen expression including 1A1, 1A2, 3A1, 5A1, and 5A2 was significantly downregulated by EC359, and this effect was synergistic with gemcitabine. *p < 0.01, **p < 0.001, ***p < 0.0001. Cont.: Control, Gem: Gemcitabine, G+E: Gemcitabine + EC359.