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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Neuropharmacology. 2019 Feb 4;149:35–44. doi: 10.1016/j.neuropharm.2019.02.003

Figure 2. Ketamine prophylactically reduces binge like drinking in female, but not male mice.

Figure 2.

(A) Saline treated male and female mice consumed similar amounts of ethanol during the week 4/day 5 binge. (B) Female mice treated with ketamine (3 mg/kg) three days before the binge drank less ethanol compared to mice administered saline. (C) Female mice administered ketamine (3 mg/kg) 12 h before the binge reduced their drinking compared to saline-injected controls. (D) Female mice were assessed for differences in ethanol-induced loss of righting reflex (LORR) following ketamine or saline. 3 mg/kg ketamine or saline was injected i.p. 12 h prior to 3.2 g/kg ethanol, i.p. No significant differences in recovery from LORR were seen. (E) Female mice were subjected to two weeks of 10% sucrose drinking-in-the-dark. Ketamine (3 mg/kg, 12 h before sucrose DID) did not alter sucrose consumption. (F) Male mice did not show ketamine-induced changes in DID, across a variety of timepoints and doses.