Table 3.
Performance of Abbreviated Screening Breast MRI
| Author, Year | N Cancersa |
N Women Screened |
CDR per 1000 screens |
Population | Biopsy Rateb (BR4 or 5, %) |
PPV3 of bx (%)c |
BR 3 | Overall Recall Rate (%) |
Magnet (T) | C+ sequences | T2/STIR | # Invasive Cancers |
Mean size (mm, range) |
Node Negative (%) |
# DCIS, grade |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kuhl, 2014 | 11 | 443 women 606 screens |
18.2 | 105 women only dense 220 PHBC 118 family hx |
45 (10.2) | 11/45 (24.4) | 53 (8.7) | 98/606 (16.2) | 1.5 | 1 axial T1 no FS |
ND | 7 | 8.4 (4–17) | 7/7 (100) | 4, all gr 2–3 |
| Jain, 2016 | 9 | 591 | 15.2 | High-risk | 39 (6.6) | 10/40 (25.0) | NS | 39/591 (6.6) | 1.5 or 3 | 1 axial T1FS | ND | 7 | NS | NS | 2d 1 gr2, 1 NS |
| Chen, 2017e | 13e | 356 | 36.5 | Dense; 6 PHBC; 29 family hx |
59 (16.6) | 13/59 (22.0)f | NSf | 59/356 (16.6) | 3 | 1 axial T1FS | NDf | 9 | All ≤ 1 cm | 9/9 (100) | 4, 1 gr2, 3 gr3 |
| Strahle, 2017 | 6g | 671 | 8.9 all 16.3 dense |
367 dense; 141 had family hx; no PHBC or known BRCA mutation |
16 (2.4) 16 (4.4) dense |
7/17 (41.2) | 0 | 16/671 (2.4) all 16/367(4.4) dense |
1.5 | 2 axial T1FS (@1.5 and 6 min) |
T2FS | 4 | 19 (7–40) | 4/4 (100) | 2g |
| Panigrahi, 2017h |
14 | 746 women 1052 screens |
13.3 | High risk | 47 (6.3) | 14/46 (30.4) | 35 (3.3) | 82/1052 (7.8) | 1.5 or 3 | 1 axial T1FS | ND | 12 | 10.7 (4–17) | NS | 2, gr 1 |
| Choi, 2018 | 12i | 725 women 799 screens |
15.0 | PHBC | 14 (1.9) | 12/19i (63.2) | 83 (10.4)i | 97/799 (12.1) | 1.5 or 3 | 1 sagittal T1FS | T2FS | 7i | 15 (5–20) | 6/7 (85.7) | 5i |
For all examinations, a scout localizer and pre-contrast T1W images were obtained; subtraction of the pre-contrast MRI from the first post-contrast MRI was performed and maximum intensity projection images were created from the subtraction images.
Abbreviations used: C+ = contrast-enhanced; ND=not done; PHBC = personal history of breast cancer; NS = not stated; BR = BI-RADS assessment; IDC = invasive ductal carcinoma; DCIS = ductal carcinoma in situ; gr = nuclear grade
Number of women found to have cancer
Biopsy rate, number of women biopsied as % of women screened
Number of biopsies malignant/total number of biopsies performed
An additional high nuclear grade DCIS was diagnosed in a patient who also had IDC on MRI
A separate publication by these authors in Academic Radiology 2017 details 16 cancers in 478 women and 41 biopsied lesions; these are likely overlapping series but extent of overlap, particularly among lesions biopsied, is unclear
An additional IDC was considered probably benign on the abbreviated protocol and suspicious when diffusion weighted imaging (DWI) was added to the abbreviated protocol; only 31 biopsies would have been performed after DWI, of which 14 were malignant
Seven malignancies were identified in six women: Two lesions of DCIS were identified in one patient (overall 3 DCIS lesions)
This series appears to entirely include what appears to be a subset published in 2016 by Harvey SC et al JACR
This institution lacked MRI-biopsy capability. 83 exams were assessed as BR3 on MRI, with 5 upgraded to BR4 at follow-up, 4 of which proved malignant, including 2 DCIS, 1 IDC, and 1 mucinous carcinoma: 4/83 (4.8%) BR3 exams proved malignant.