Fig. 4.

Summary of the findings. (Blue) In basal condition, healthy cells show no activated UPR and no mitochondrial dysregulation, whereas an acute-induced ER stress by Th activates the UPR and increases MMP and ATP level. (Red) Both AD model show an activated UPR in basal condition and differently impaired mitochondrial function, such as MMP and ATP level. An additional acute Th-induced ER stress further activates the UPR and decreases MMP and ATP level in both tau-overexpressing cells; however, APP/Aβ-overexpressing cells already show some cell toxicity, displayed by increased LDH level