Table 1.
Histone modifiers required for the directionality of mating-type switching in S. pombe
| Modification | Name | Description | Complex |
|---|---|---|---|
| HDAC | Sir2 | Sirtuin family (NAD-dependent) histone deacetylase Sir2 | |
| Clr1 | SHREC complex subunit Clr1 | SHREC | |
| Clr2 | Chromatin silencing protein Clr2 | ||
| Clr3 | Histone deacetylase (class II) Clr3 | ||
| H3K9 methyl transferase | Clr4 | Histone H3 lysine methyltransferase Clr4 | CLRC |
| Rik1 | CLRC ubiquitin ligase complex WD repeat protein Rik1 | ||
| Raf1 | CLRC ubiquitin ligase complex WD repeat subunit Raf1 | ||
| Raf2 | CLRC ubiquitin ligase complex subunit Raf2 | ||
| H3K4 methyl transferase | Set1 | Histone lysine methyltransferase Set1 | Set1C |
| Swd1 | Set1C complex subunit Swd1 | ||
| Swd2 | Set1C complex subunit Swd2.1 | ||
| Swd3 | WD repeat protein Swd3 | ||
| Ash2 | Ash2-trithorax family protein | ||
| Spf1 | Set1C PHD Finger protein Spf1 | ||
| H2BK119 ubiquitination | Brl2 | Ubiquitin-protein ligase E3 Brl2 | HULC |
The factors listed were identified, among other factors, in a search for directionality mutants (Maki et al. 2018)