Table 2.

The relative concentrations of differential metabolites in response to treatment with GPr by intraperitoneal injection in mice. Similarity value (SV) was used to evaluate the accuracy of the discriminating metabolite. Variable importance in the projection (VIP) was obtained from OPLS-DA with a threshold of 1.0. p-Value was calculated from Student's t-test. The red and blue arrows indicate up and down trends.

Metabolites	SV	Control	GPr	VIP	P-VALUE	Trend
Inosine	933	230	0.26883496	0.474806953	1.403129
Aspartic acid 1	930	232	1.394412343	2.302817461	1.95754
3-Hydroxybutyric acid	896	147	0.03413712	0.057421069	1.790805
Phosphate	826	373	9.58593E-07	0.003834269	2.238158
2-Monopalmitin	761	218	0.000916024	0.007080175	1.305231
2-Monoolein	725	103	0.007766589	0.0193021	1.57449
cis-Gondoic acid	697	175	9.58593E-07	0.013856645	2.387345
Inosine 5′-monophosphate	687	315	9.58593E-07	0.001733039	2.083737
Nicotinic acid	586	180	0.001234995	0.004313206	2.41329
Dihydroxyacetone	558	163	0.000153415	0.000706533	1.70357
Linoleic acid methyl ester	542	86	0.022472983	0.055198241	1.340144
m-Cresol	534	165	0.001404886	0.002949009	1.930035
Mannitol	517	319	0.001031488	0.002153881	1.063901
Cortisone	499	103	9.58593E-07	0.006679172	1.942847
2-Hydroxyvaleric acid	446	102	0.000877641	0.001813946	1.95695
Phosphoglycolic acid	425	299	0.005146486	0.013489075	1.927157
Phytanic acid	357	159	0.004245082	0.001927866	1.541776
3,4-Dihydroxypyridine	337	256	0.003866274	0.007287569	1.81441
3,5-Dihydroxyphenylglycine 1	316	283	0.003695243	0.010222014	1.836686
Hexadecane	279	199	0.017033444	0.030171359	2.100437
Creatine degr	276	316	0.000734181	0.001345046	1.841828
4-Hydroxymethyl-3-methoxyphenoxyacetic acid	241	366	0.001093006	0.000727609	1.032588
trans-2-Hydroxycinnamic acid	226	219	0.00088091	0.001805154	1.16949