Table 2.
Most probable metabolites for spilanthol, with their respective chemical reactions, probability values, and predicted DL50.
| Metabolites | Phase type | Chemical Reaction | Probability (PR) | DL50 |
|---|---|---|---|---|
| M8 | Phase I reaction (Oxidation) | Epoxidation | 0,9991 | 46.49 mg/kg |
| M18 | Phase II biotransformation reaction | N- Acetylation | 0,8985 | 26.28 mg/kg |
| M26 | Phase I reaction (Oxidation) |
aliphatic hydroxylation | 0,8072 | 33.14 mg/kg |
| M28 | Phase II biotransformation reaction | Glutathionation | 0,7797 | 327.74 mg/kg |
| M33 | Phase I reaction (Oxidation) |
C-oxidation | 0,6322 | 28.69 mg/kg |
| M35 | Phase II biotransformation reaction | N-glucuronidation | 0,5135 | 81.34 mg/kg |