Table 2. Univariate and multivariate analyses for liver metastasis.
| Parameter | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age ≥60 years | 1.03 (0.76–1.40) | 0.839 | 0.96 (0.70–1.31) | 0.788 |
| Gender: Male | 1.18 (0.84–1.66) | 0.335 | 1.22 (0.86–1.74) | 0.268 |
| T category | ||||
| T1 | 1 | 1 | ||
| T2 | 2.23 (1.20–4.15) | 0.011 | 1.93 (1.03–3.61) | 0.042 |
| T3 | 2.20 (1.12–4.33) | 0.022 | 1.41 (0.70–2.82) | 0.335 |
| T4 | 3.02 (1.62–5.63) | <0.001 | 1.77 (0.93–3.39) | 0.082 |
| N category | ||||
| N0 | 1 | 1 | ||
| N1 | 1.10 (0.51–2.39) | 0.817 | 1.01 (0.46–2.21) | 0.990 |
| N2 | 3.10 (1.92–4.99) | <0.001 | 2.71 (1.65–4.47) | <0.001 |
| N3 | 4.52 (2.75–7.42) | <0.001 | 3.59 (2.10–6.13) | <0.001 |
| Histology squamous | 1.27 (0.93–1.74) | 0.140 | 1.28 (0.93–1.77) | 0.140 |
| ALT or AST ≥40 U/L | 0.97 (0.57–1.66) | 0.923 | 0.81 (0.47–1.42) | 0.467 |
| Hepatitis virus | 1.25 (0.81–1.93) | 0.306 | 1.30 (0.83–2.04) | 0.246 |
| Diabetes mellitus | 1.10 (0.66–1.85) | 0.707 | 1.12 (0.67–1.90) | 0.662 |
| BMI ≥25 kg/m2 | 1.27 (0.90–1.78) | 0.177 | 1.07 (0.75–1.53) | 0.709 |
| Hepatic Steatosis | 1.42 (1.03–1.96) | 0.032 | 1.43 (1.02–2.01) | 0.039 |
| Surgery | 0.45 (0.31–0.63) | <0.001 | 0.57 (0.38–0.84) | 0.005 |
| Chemotherapy | 1.21 (0.20–2.09) | 0.504 | 0.76 (0.43–1.34) | 0.346 |
| Radiotherapy | 0.72 (0.50–1.05) | 0.087 | 0.57 (0.39–0.83) | 0.003 |
Note:
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; HR, hazard ratio; CI, confidence interval.