Table 3. Univariate and multivariate analyses for overall metastasis.
| Parameter | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age ≥60 years | 1.00 [0.87–1.16] | 0.959 | 0.95 [0.82–1.10] | 0.490 |
| Gender. male | 1.00 [0.86–1.17] | 0.97 | 1.10 [0.94–1.29] | 0.248 |
| T category | ||||
| T1 | 1 | 1 | ||
| T2 | 2.23 [1.71–3.10] | <0.001 | 1.90 [1.40–2.57] | <0.001 |
| T3 | 2.29 [2.12–3.99] | <0.001 | 1.92 [1.39–2.65] | <0.001 |
| T4 | 3.29 [2.44–4.42] | <0.001 | 1.97 [1.45–2.67] | <0.001 |
| N category | ||||
| N0 | 1 | 1 | ||
| N1 | 1.52 [1.11–2.11] | 0.010 | 1.28 [0.92–1.77] | 0.141 |
| N2 | 3.19 [2.56–3.97] | <0.001 | 2.41 [1.92–3.02] | <0.001 |
| N3 | 3.87 [3.07–4.88] | <0.001 | 2.52 [1.97–3.22] | <0.001 |
| Histology squamous | 0.78 [0.67–0.92] | 0.002 | 0.75 [0.64–0.88] | 0.001 |
| ALT or AST ≥40 U/L | 1.30 [1.04–1.62] | 0.023 | 1.14 [0.90–1.44] | 0.285 |
| Hepatitis virus | 1.26 [1.03–1.54] | 0.026 | 1.21 [0.98–1.50] | 0.071 |
| Diabetes mellitus | 1.0 2 [0.79–1.31] | 0.898 | 1.09 [0.84–1.41] | 0.520 |
| BMI ≥25 kg/m2 | 1.13 [0.96–1.33] | 0.152 | 1.05 [0.89–1.24] | 0.584 |
| Hepatic steatosis | 1.03 [0.88–1.21] | 0.693 | 0.99 [0.84–1.17] | 0.895 |
| Surgery | 0.38 [0.32–0.49] | <0.001 | 0.53 [0.44–0.64] | <0.001 |
| Chemotherapy | 2.07 [1.52–2.82] | <0.001 | 1.22 [0.89–1.67] | 0.224 |
| Radiotherapy | 1.43 [1.23–1.67] | <0.001 | 1.13 [0.97–1.33] | 0.119 |
Note:
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; HR, hazard ratio; CI, confidence interval.