Table 3:
Reported new or worsened sleep symptoms in AE patients, stratified by disease-associated autoantibody.
| Autoantibody | Reported Sleep Symptom, n (%) |
|---|---|
| AMPA | Any symptom, 2 (100) |
| Hypersomnia, 1 (50) | |
| Insomnia, 1 (50) | |
| Snoring or gasping, 1 (50) | |
| CRMP5* | Any symptom, 1 (100) |
| Insomnia | |
| GABA | Any symptom, 1 (100) |
| Hypersomnia | |
| Snoring or gasping, witnessed apnea | |
| Hu* | Any symptom, 3 (100) |
| Insomnia, 1 (33) | |
| Witnessed apnea, 2 (66) | |
| LGI1 | Any symptom, 6 (86) |
| Dream enactment 4 (57) | |
| Restless sleep, 3 (43) | |
| Somniloquy, 3 (43) | |
| Snoring or gasping, 2 (29) | |
| Insomnia, 2 (29) | |
| Limb movements during sleep, 2 (29) | |
| Somnambulism, 1 (14) | |
| Dream-wake confusion, 1 (14) | |
| Restless legs symptoms, 1 (14) | |
| Vivid dreams, 1 (14) | |
| Ma1/Ma2 | Any symptom, 1 (50) |
| Hypersomnia | |
| Insomnia | |
| Limb movements during sleep | |
| Restless legs symptoms | |
| Snoring or gasping | |
| NMDAR* | Any symptom, 5 (56) |
| Dream enactment, 2 (22) | |
| Insomnia, 2 (22) | |
| Snoring or gasping, witnessed apnea 2 (22) | |
| Dream-wake confusion, 1 (11) | |
| Restless sleep, 1 (11) | |
| Somniloquy, 1 (11) | |
| VGCC | Any symptom, 0 |
| Yo | Any symptom, 1 (100) |
| Hypersomnia |
*
One patient presented with AE associated with Hu, CRMP5, and NMDAR autoantibodies [23]