Table A2.
H2 of psychiatric diagnoses based on ICD 8, 9 , and 10, with the younger sibling being at least as old as the median age of diagnosis
| Frequencies | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Full siblings | Maternal half-siblings | Tetrachoric correlation | ||||||||
| Cases | Controls | Prevalence (%) | Cases | Controls | Prevalence (%) | Median age of disorder onset | Full sibs | Maternal half sibs | h2 | |
| Schizophrenia | 14 188 | 2 335 292 | 0.60 | 967 | 112 193 | 0.85 | 34 | 0.326 (0.010) | 0.053 (0.059) | 0.564 (0.050) |
| Bipolar | 14 496 | 2 184 334 | 0.66 | 998 | 103 240 | 0.96 | 37 | 0.297 (0.011) | 0.166 (0.048) | 0.525 (0.197) |
| ADHD | 10 452 | 408 760 | 2.49 | 2308 | 21 324 | 9.77 | 16 | 0.455 (0.009) | 0.257 (0.024) | 0.807 (0.104) |
| Autism | 4900 | 414 312 | 1.17 | 653 | 22 979 | 2.76 | 16 | 0.410 (0.015) | 0.223 (0.049) | 0.748 (0.204) |
| MDD | 82 840 | 2 063 646 | 3.86 | 6642 | 94 294 | 6.58 | 38 | 0.169 (0.004) | 0.108 (0.016) | 0.242 (0.065) |
| Anorexia | 8706 | 3 277 732 | 0.26 | 700 | 177 898 | 0.39 | 16 | 0.211 (0.019) | 0.115 (0.075) | 0.375 (0.309) |
| OCD | 9478 | 2 751 410 | 0.34 | 781 | 139 567 | 0.56 | 26 | 0.222 (0.016) | 0.155 (0.053) | 0.267 (0.220) |
| SUDS & Alcohol | 66 035 | 2 080 451 | 3.08 | 6481 | 94 455 | 6.42 | 38 | 0.265 (0.005) | 0 .177 (0.015) | 0.351 (0.065) |
Note. Standard errors are presented in parentheses.
Sex and age were regressed out from all disorders.
For ADHD and autism, birth year was limited to 1990 or higher.
Youngest sibling being at least as old as disorder median age of onset or later.