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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: J Eukaryot Microbiol. 2018 Oct 5;66(3):460–468. doi: 10.1111/jeu.12690

Table 2.

Effects of 2-deoxy-D-glucose (2DG), 2-deoxy-D-glucose-6-phosphate (2DG6P) and fluorodeoxyglucose (FDG) on CpHK, HsHK1 and CpGPI enzyme activities

Inhibitor Effects of compounds on enzymes
CpGPI CpHK HsHK1
2DG Ineffective at ≤50 mM IC50 = 5.75 mM IC50 = 10.1 mM
2DG6P Ineffective at ≤28 mM Ineffective at ≤28 mM Ineffective at ≤28 mM
FDG Ineffective at ≤150 mM IC50 = 3.7 mM IC50 = 15.2 mM