. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: J Eukaryot Microbiol. 2018 Oct 5;66(3):460–468. doi: 10.1111/jeu.12690

Table 4.

Inhibition of the CpHK and HsHK1 enzyme activity by the top four hits identified from 1200 existing drugs and their efficacies against the growth of C. parvum in vitro

Compound	Inhibition on CpHK (IC₅₀, μM)	Inhibition on HsHK1 (IC₅₀, μM)	Selectivity on enzyme	Efficacy on C. parvum (EC₅₀, μM)	Cytotoxicity (TC₅₀, μM)	Safety interval (SI)	Compound description
Alexidine•2HCl	22.1	22.7	1.03	8.1	32.6	4.02	Biguanide compound; Antibacterial, detergent, oral disinfectant, apoptosis promotic agent
Ebselen	0.241	0.265	1.10	165^*	700^*	4.24	Organoselenium compound; Anti-inflammatory, anti-thrombotic, anti-atherosclerotic, anti-oxidant
Hexachlorophene	8.8	6.5	0.74	0.53	100	188.7	Organochlorine compound; Antiseptic, bacteriostatic, anti-helminthic
Thimerosal	2.3	0.35	1.52	1.77	18.5	10.5	Organomercury compound; Antiseptic, antifungal, vaccine preservative

Data adapted from a previous study (Eltahan et al, 2018).