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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Mol Neurobiol. 2018 Sep 17;56(6):3904–3921. doi: 10.1007/s12035-018-1344-x

Table 1:

Summary of Cited Alzheimer’s Disease Mouse Model Data

Phenotype 3XTg 5XFAD APPE693Q APPSWE/PS1ΔE9 FRAXAD J20 R1.40 Tg2576 ArcSWE
Mutated Genes* APPSWE MAPTP301L PSEN1M146V APPSWE APPFLOR APPLOND PSEN1M146L PSEN1L286V APPDUTCH APP PSEN1ΔE9 APPSWE Fmr1KO APPSWE APPIND APPSWE APP APPSWE APPArc
APP Gene Contains UTR Sequences No [133] Yes [134] No [59] Yes [135] Yes [136] No [33] Yes [137]
Early Mortality Yes [110] Yes [59] Yes [59]
AGS Susceptibility Yes [114] Yes [111] No [113] No [113] Yes [111]
Anti-Aβ Rescues Seizures Yes [114] Yes [111]
Epilepti form Discharge Duration
 Yes [114]
mGlu R5 Inhibitors or Genetic Knockout Rescues Seizures Yes [114] Yes [37] Yes [37,111]
Aβ Levels or Plaques Yes [61] Yes [47,61] Yes [53] Yes & No** [53]
Dendritic spine or synapse loss Yes [75,86]
Early Mortality Yes [110]
Epilepti form Yes [114]
Discharge Duration
Learning / Memory
 Yes [75] Yes [47,61,75,86]
Altered Expression of mGluR5 Yes [73] Yes [47]
Fmr1 gene Differentially Spliced Yes [103] Yes [103]
FMRP Differentially Expressed No [45] Yes [47] Yes [46]
*

APPSWE = APP KM670/671NL (APP with Swedish familial AD mutation); APPFLOR = APP I716V (APP with Florida familial AD mutation); APPLOND = APP V717I (APP with London familial AD mutation); APPDUTCH = APP E693Q (APP with Dutch familial AD mutation); APPIND = APP V717F (APP with Indiana familial AD mutation); APPARC = APP E693G (APP with Arctic familial AD mutation); MAPT P301L (tau familial AD mutation); PSEN1 (presenilin 1 familial AD mutation).

**

Human Aβ produced from the transgene is not reduced. Endogenous mouse Aβ is reduced.