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. 2019 Mar 14;25(10):1171–1184. doi: 10.3748/wjg.v25.i10.1171

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Approach to patients with diarrhoea. Summary of causes of diarrhoea in patients with gastroenteropancreatic neuroendocrine neoplasms, how to analyse and treatment advise. ¹Optimise SSA’s: Increase dose, shorten interval or add short acting dose; ²Advise loperamide: Increasing dose 2-4-8 mg 4 times a day, up to 12-24 mg 4 times a day in short bowel syndrome; ³Advise codeine: 15-60 mg 4 times a day; Advise PERT: 1 × 25000 units of lipase per small meal 2 × 25000 units lipase per large meal, titrate up may need > 80000 units per large meal. SSA’s: Somatostatin analogue’s; SeHCAT: Selenium homotaurocholic acid conjugated with taurine; BOD: Twice a day; PERT: Pancreatic enzyme replacement therapy.