Figure 3.

C57BL/6 lineages and the divergence of stroke vulnerability. (a) Infarct size variation across an expanded substrain set. Results are shown for pooled male and female mice of J, ByJ, NCrl and NJ substrains from Figure 1, together with more limited data for JEiJ and NTac substrains. Symbols indicate mean ± SEM with group sizes in parentheses. (b) C57BL/6 substrain lineages. Origins of the six evaluated substrains illustrate their relationship to the pattern of stroke vulnerability. The responsible mutation appears to have occurred at NIH (*), subsequent to the separation of the ByJ lineage in 1961 and prior to the transfer of mice to Charles River in 1974.