Figure 6.

Substrain differences in infarct size are independent of acute perfusion deficits. (a) Speckle contrast imaging. Mean contralateral perfusion did not differ significantly in mice with large (N) and small (J) stroke phenotypes. J/ByJ/JEiJ mice had lower penumbral perfusion than NJ/NCrl mice, but as a percentage of contralateral flow, this did not achieve statistical significance. Inset shows a representative image and identifies regions of interest sampled for the measurements. (b) Penumbral perfusion and stroke outcome. Infarct volume was inversely related to the residual blood flow within a strain pool, but J/ByJ/JEiJ mice tended to exhibit smaller infarcts than NJ/NCrl mice for a given flow value. Lines indicate linear regression for the respective groups. Animal numbers (male, female) were as follows in the J pool: C57BL/6 J (4, 0), ByJ (12, 7), JEiJ (2, 0); and in the N pool: NJ (9, 13), NCrl (10, 6).