Figure 2.

Development-related changes in brain for two select structural ROIs. (a, d) CBF reached adult levels at approximately the same time in precuneus and SFG; however, SFG had a later peak CBF in childhood at approximately age 8 or 9. The peak for precuneus was not detectable in this age range. (b, e) Regional glucose consumption declined in both regions until reaching approximately the same level in adulthood for males and females. (c, f) %RMR decreases in both sexes for both regions. Female’s curves leveled at a higher resting value by age 15. Fitted curves are estimated with generalized additive models (GAMs). Dashed lines are 95% simultaneous confidence intervals; Est: estimated.