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. 2019 Mar 11;10:127. doi: 10.3389/fendo.2019.00127

Table 3.

Descriptive statistics of B-mode and elastographic parameters discriminating benign from malignant thyroid lesions (PPV, positive predictive value; NPV, negative predictive value; sensitivity, specificity, Youden index, sum-sensitivity+specificity).

Parameter Youden index Sensitivity (%) 95% CI (sensitivity) Specificity (%) 95% CI (specificity) PPV (%) 95% CI (PPV) NPV (%) 95% CI (NPV) Sum
Margins 0.51 66.33 56.51–74.91 84.54 78.99–88,83 67.01 57.16–75.56 84.13 78.56–88.47 302.01
Markedly hypoechoic 0.21 28.57 20.57–38.19 92.75 88.39–95.56 65.12 50.17–77.58 73.28 67.62–78.28 259.72
Microcalcifications 0.37 64.29 54.43–73.07 72.95 66.52–78.54 52.94 44.02–61.68 81.18 74.96–86.15 271.36
Thyroid capsule infiltration 0.22 37.76 28.79–47.64 84.06 78.46–88.42 52.86 41.32–64.10 74.04 68.08–79.23 248.71
Macrocalcifications 0.21 38.78 29.73–48.67 82.61 76.86–87.17 51.35 40.18–62.39 74.03 68.01–79.25 246.76
Asteria scale 0.34 44.90 35.43–54.75 89.37 84.43–92.88 66.67 54.66–76.84 77.41 71.69–82.25 278.34
“Halo” pattern 0.17 94.90 88.61–97.80 21.74 16.66–27.85 36.47 30.80–42.54 90.00 78.64–95.65 243.11
Composition (solid) 0.16 69.39 59.68–77.64 46.86 40.18–53.65 38.20 31.38–45.52 76.38 68.28–82.92 230.83
Tall/wide 0.17 68.37 58.62–76.73 48.31 41.59–55.09 38.51 31.60–45.91 76.34 68.37–82.80 231.52