Table 1.

Summary of temporal clusters.

Cluster	Notable genes	Top GO biological process (fold enrichment >10, p < E-05)	TFBS >10 genes
1	MCL1, IRF4	Type I interferon signaling pathway, endoplasmic reticulum unfolded protein response, cellular response to unfolded protein	ETS2 (11 genes p < 0.0012), AP4 (12 genes p < 0.0019), SP1 (17 genes p < 0.0036), NFAT (12 genes p < 0.0088)
2	CD27, PRDM2, IRF1, XBP1	Protein exit from endoplasmic reticulum	SP1 (14 genes p < 0.0026), LEF1 (13 genes p < 0.0039)
3	CD38, CD79A	Protein N-linked glycosylation via asparagine	SP1 (25 genes p < 2.3e-5), LEF1 (21 genes p < 0.00026), MYC (11 genes p < 0.0006), PAX4 (11 genes p < 0.0038)
4	BCL11A, CD19, IL4R	NS	MAZ (17 genes p < 0.0001), NFY (12 genes p < 0.00012), AP4 (12 genes p < 0.0005), FOXO4 (13 genes p < 0.0011), SP1 (15 genes p < 0.0027)
5	AICDA, CCL17, CCL22, FAS, IRF8, MYB	DNA replication	SP1 (17 genes p < 0.00026), MAZ (11 genes p < 0.0118), LEF1 (12 genes p < 0.0152) E12 (11 genes p < 0.0153)
6	BATF3, BCL6, CD79B, CD83, SPIB	Mitosis	E2F (11 genes p < 7.3e-9), SP1 (33 genes p < 7.2e-9), ETS (19 genes p < 2.2e07), LEF1 (28 genes p < 1.4e-6), E12 (26 genes p < 1.5e-6), MYC (15 genes p < 1.3e-5), PU1 (12 genes p < 1.2e-5)

The top GO biological processes with the lowest P-value and a fold enrichment threshold of >10 are shown. TFBS significant at 5% threshold and known to regulate >10 genes are shown. For a list of genes related to each of the clusters see Supplementary Table 1. (ns, Not significant).