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. 2019 Feb 25;116(11):5126–5134. doi: 10.1073/pnas.1814456116

Fig. 2.

Fig. 2.

Glial expression of ATRX syndrome gene dATRX/XNP is required for somatodendritic wrapping of sensory neurons. (A) Third-instar larvae expressing ppk-CD4-tdGFP (green) and Repo-Gal4 > CD4-tdTomato (magenta) to visualize neuron and glia, respectively, either alone (W1118), with UAS-dATRX RNAi, or UAS-dATRX dominant-negative (DN) (K495R) are shown. Extent of glial coverage of the somatodendritic compartment of class IV neurons is evident in the merged image. (Scale bar, 10 μm.) (B) Percent area of somatodendritic neuronal surface wrapped by glia in control, two independent dATRX RNAi lines, and dATRX DN third-instar larvae is plotted (n = 15, 15, 11, and 11, respectively, t test, P < 0.0001). (C) Total length of dendrite per neuron wrapped by glia in control, two independent dATRX RNAi lines and dATRX DN third-instar larvae (n = 15, 15, 11, and 11, respectively, t test, P < 0.0001) is plotted.