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. 2019 Feb 25;116(11):5126–5134. doi: 10.1073/pnas.1814456116

Fig. 7.

Fig. 7.

Loss of dATRX in subperineurial layer is sufficient to disrupt somatodendritic neuronal ensheathment. Class IV da neurons expressing the neuronal marker ppk-CD4-tdTomato (green) along with UAS-CD4-tdGFP with or without UAS-dATRX RNAi driven by glial layer specific Gal4. (A) The 46F-Gal4 drives expression in the perineurial glia (magenta) and the neuron is marked by ppk-CD4-tdTomato (green). The extent of somatodendritic glial coverage is unaffected by dATRX knockdown in perineurial glia. (B) The effect of dATRX knockdown in subperineurial glia layer is visualized using the Gli-Gal4 driving expression of membrane tagged GFP and UAS-dATRX RNAi in the subperineurial glia (blue). (C) The wrapping glia layer visualized using the Nrv2-Gal4 (red) is unaffected by dATRX knockdown. The extent of neuronal surface ensheathed by each layer of glia is observable in the merge panels. (Scale bar, 10 μm.)