Fig. 6.

Multiple dynamic contacts form within the hub. (A) Hierarchical looping accommodates four simultaneous loops in an individual fiber. One folded HOXC gene cluster fiber is shown with a sketch demonstrating the fiber folding and the genes and fiber-folding pattern and the corresponding contact probability matrix. (B) Cartesian distances between promoter regions of four gene pairs are plotted as a function of simulation length in a single trajectory. Fiber snapshots, with the promoters highlighted in green and yellow, demonstrate the formation of transient connections between promoters. MC, Monte Carlo.