Fig. 3.
Mtln inactivation reduces respiratory complex I activity. (A) Oxygen consumption rates for complexes I–IV for parental NIH 3T3 and ∆Mtln knockout cell lines. Values are average of three independent experiments done in triplicates. For the statistically significant changes, multiplicity adjusted P value (P < 0.05, Student’s t test, Holm–Sidak correction) is indicated. (B) Oxygen consumption rates for mitochondria isolated from parental NIH 3T3 and ∆Mtln cell lines. Values are average of three independent experiments done in triplicates. For the statistically significant changes, multiplicity adjusted P value (P < 0.05, Student’s t test) is indicated. For A and B data are presented as mean ± SD.