Table 5. In Vitro ADME Properties of Boronpleuromutilins.

ID	mouse S9 Clint (μL/min/mg)	mouse protein binding (funbound @ 2 μM)	MDR1-MDCK Pappa
2	4	0.218	0.2
3	41	0.154	6.7
4	131	0.26b	22.1
5	NT	0.05b	1.4
8	145	0.003	15.1
9	168	0.002	NTc
10	139	0.005	NT
11	77	<0.001	NT
12	136	0.012	NT
14	117	0.003	NT
15	33	0.034	14.1
16	44	0.008	NT
19	NT	0.116	0.3
20	7	0.110	0.1
21	NT	0.119	0.5
23	NT	0.048	0.1
25	102	0.008	36.5
26	2	0.306	0.1
32	NT	0.005	22.6
33	142	0.008	9.0
40	226	0.058	6.6
41	NT	0.007	NT
42	NT	0.005	NT
44	80	0.008	2.3
45	NT	0.037	NT
46	NT	<0.001	8.8
52	217	0.006	NT
53	NT	<0.001	NT
55	NT	NT	8.7
59	53	0.033	3.7

^aPermeability measured in a Madin Darby canine kidney cell monolayer transfected with the multidrug resistance 1 (mdr1) gene encoding P-glycoprotein MDR1.

^bProtein binding measured at 1 μM.

^cNT = not tested.