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. 2019 Feb 23;10(3):348–351. doi: 10.1021/acsmedchemlett.8b00634

Table 2. Solubility, Melting Points, and tPSA of 5, 7, 9, and 12.

Compounds Solubility (μg/mL) mp (°C) tPSAa
PBTZ169 <1 × 10–2 183–185 87.7
5 4.8 ± 0 110–112 96.5
7 14.6 ± 0.1 >250 87.7
9 <2.9 × 10–2 209–211 87.7
12 0.30 ± 0.02 192–194 84.5
a

tPSA was calculated by Chembiodraw Ultra version 15.0.