Table 3. Microsomal Stability, Plasma Protein Binding, and Plasma Stability of Compounds 5, 7, 9, 12, and PBTZ169.

	t1/2 (min)		Clint (μL·min–1·mg–1)
	MLM	HLM	MLM	HLM	PPB (%)	Plasma Stability (%)
PBTZ169	34.4	43.0	20.1	16.5	99.9	88.7
5	65.2	76.6	10.6	9.05	99.5	91.4
7	7.05	26.6	98.4	26.1	99.6	81.9
9	27.3	30.6	25.4	22.7	99.9	102
12	8.33	43.0	83.3	16.1	99.4	93.3