Figure 3.

Conformational searchs results for TCN-201 (9) and the diaryl sulfonamides comparing the shapes adopted when sulfonamide and amide linkers of two different lengths are used. (A) Lowest-energy conformer for each TCN-201 (9) (left) and compound 26 (right), a compound in which the sulfonamide of TCN-201 has been replaced with an amide. (B) Lowest-energy conformer for each 23 (upper) and the corresponding analog 27 (lower) in which the sulfonamide is replaced by an amide. (C) All 50 conformers resulting from the conformational search for compound 18 containing a methylene in the sulfonamide linker (left) and compound 23 containing an ethylene in the sulfonamide linker (right) are superimposed.