Table 2. Activity of Bi-aryl Sulfonamides^a.

						I30μM/Icontrol (mean ± SEM, %) IC50 (μM)b
Cmpd #		n	R1	R2	Y	GluN2C	GluN2D
16	para	1	H	H	CH	42 ± 2.5	20 ± 2.5
						22	10
17	para	1	H	H	N	58 ± 4.6	45 ± 3.3
						35	24
18	meta	1	H	H	CH	60 ± 2.0	46 ± 2.6
						45	29
19	meta	1	H	H	N	52 ± 1.4	42 ± 1.3
						34	23
20	para	2	H	H	CH	77 ± 2.9	67 ± 4.4
						ND	ND
21	para	2	H	H	N	37 ± 2.8	26 ± 4.1
						12	5.1
22	para	2	Cl	F	CH	79 ± 1.4	74 ± 2.0
						ND	ND
23	meta	2	H	H	CH	9.0 ± 2.8	9.0 ± 2.3
						2.4	1.7
24	meta	2	H	H	N	8.5 ± 1.3	8.6 ± 1.4
						3.2	2.7
25	meta	2	Cl	F	CH	41 ± 1.6	28 ± 2.6
						2.4	1.3

^aThe response to drug coapplied with a maximally effective concentration of glutamate (100 μM) and glycine (30 μM) is given as a percent of the control response to glutamate and glycine alone.

^bFitted IC₅₀ values are reported to two significant figures; inhibition in saturating test compound was set to 0 for all except 16, which was 41% for GluN2C and 27% for GluN2D. ND indicates not determined. Data are from 8 to 16 oocytes from 2 to 3 frogs for each compound and receptor tested.