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. 2019 Feb 21;10(3):295–299. doi: 10.1021/acsmedchemlett.8b00410

Scheme 2. Synthesis of Compounds 6m and 6n.

Scheme 2

Reagents and conditions: (a) HATU, DIEA, DCM, rt, overnight, 70%; (b) TFA, DCM, rt, 2 h, 98%; (c) Cs2CO3, EtOH, DMF, rt, overnight, 46%, (d) ammonium acetate, xylene, 140°C, 6 h, 56%; (e) acetamide, xylene, 140°C, 3 h, 45%.