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. Author manuscript; available in PMC: 2019 Mar 18.
Published in final edited form as: Adv Pharmacol. 2013;68:223–233. doi: 10.1016/B978-0-12-411512-5.00011-7

Figure 11.1.

Figure 11.1

Overview of cellular copper metabolism. In neuronal cells, ATP7A is required for maturation of DBH and PAM. ATOX1, copper transport protein ATOX1; ATP7A, copper-transporting ATPase 1; ATP7B, copper-transporting ATPase 2; CCS, copper chaperone for SOD1; CCO, cytochrome c oxidase; COX11, cytochrome c oxidase assembly protein Cox11; Cox17, cytochrome c oxidase copper chaperone; CP, ceruloplasmin; CTR, copper transporter 1; DBH, dopamine-β-hydroxylase; DMT1, divalent metal transporter 1; PAM, peptidylglycine α-amidating monooxygenase; Sco1, protein SCO1 homologue; SOD1, superoxide dismutase. Reproduced from Kaler (2011), with permission.