Table 2.
Association between maternal organochlorine pesticide exposure and communication development scores in daughters at 15 months.*
| Nonverbal Communication |
Social Development |
Verbal Comprehension |
Vocabulary Comprehension & Production |
|||||
|---|---|---|---|---|---|---|---|---|
| Analyte Tertiles (ng/g lipid) | Adjusted mean (95% CI) |
P*** | Adjusted mean (95% CI) |
P*** | Adjusted mean (95% CI) |
P*** | Adjusted mean (95% CI) |
P*** |
| p,p’-DDE (n = 375) | ||||||||
| 1 ( ≤ 229.5) | 15.38 (14.76, 15.07) | 18.77 (17.67, 19.86) | 9.77 (9.32, 10.21) | 97.27 (88.71, 105.84) | ||||
| 2 (229.51–420.0) | 14.52 (13.96, 15.08) | 0.94 | 18.35 (17.36, 19.35) | 0.97 | 9.42 (0.01, 9.83) | 0.46 | 95.05 (87.30, 102.81) | 0.76 |
| 3 (> 420.0) | 14.48 (13.90, 15.07) | 0.06 | 18.33 (17.29, 19.36) | 0.59 | 9.64 (9.22, 10.06) | 0.71 | 96.80 (88.72, 105.84) | 0.94 |
| p-trend** | 0.11 | 0.65 | 0.93 | 0.98 | ||||
| p,p’-DDT (n = 363) | ||||||||
| 1 ( ≤ 9.0) | 14.88 (14.31, 15.44) | 17.80 (16.79, 18.81) | 9.29 (8.88, 9.70) | 94.98 (86.99, 102.97) | ||||
| 2(9.01–14.7) | 14.57 (14.01, 15.14) | 0.17 | 19.02 (18.01, 20.02) | 0.73 | 9.45 (9.04, 9.87) | 0.04 | 99.21 (91.24, 107.18) | 0.66 |
| 3 (> 14.7) | 15.16 (14.55, 15.77) | 0.52 | 18.76 (17.67, 19.85) | 0.22 | 10.10 (9.65, | 0.01 | 96.57 (87.94, 101.21) | 0.80 |
| p-trend** | 0.40 | 0.31 | 10.54) 0.008 | 0.88 | ||||
| HCB (n = 375) | ||||||||
| 1 ( ≤ 41.2) | 14.92 (14.31, 15.52) | 18.35 (17.29, 19.41) | 9.70 (9.26, 10.13) | 105.38 (97.12, 113.64) | ||||
| 2 (41.21–59.0) | 15.20 (14.66, 15.75) | 0.02 | 19.26 (18.29, 20.22) | 0.04 | 9.85 (9.45, | 0.05 | 95.60 (88.11, 103.08) | 0.21 |
| 3 (> 59.0) | 14.19 (13.57, 14.80) | 0.12 | 17.77 (16.69, 18.84) | 0.47 | 10.24) 9.25 (8.81, | 0.19 | 88.35 (80.00, 96.71) | 0.01 |
| p-trend** | 0.10 | 0.43 | 9.70) 0.17 | 0.007 | ||||
| β-HCH (n = 374) | ||||||||
| 1(< 39.05) | 15.26 (14.61, 15.92) | 19.56 (18.40, 20.71) | 9.94 (9.47, 10.41) | 104.54 (95.55, 113.53) | ||||
| 2 (39.06–56.15) | 14.58 (14.04, 15.11) | 0.95 | 17.81 (16.88, 18.75) | 0.49 | 9.61 (9.22, 9.99) | 0.39 | 93.51 (86.23, 100.79) | 0.91 |
| 3 ( ≥ 56.15) | 14.61(14.01, 15.20) | 0.18 | 18.32 (17.27, 19.36) | 0.14 | 9.35 (8.92, 9.78) | 0.09 | 92.83 (84.67, 101.00) | 0.08 |
| p-trend** | 0.25 | 0.28 | 0.10 | 0.12 | ||||
*
Adjusted for home score at six months, maternal age, parity, smoking status. Pesticides lipid-adjusted with units ng/g lipid.
**
P-trend based on a scored variable using the median value of each tertile.
***
P-values based on the comparison between the category with the lowest category (referent).